![]() Protein ligand interaction Proteins could be: Ligands would be: enzymes substrates, allosteric regulators receptors chemical messengers transporters transported substances transcription factors transcription regulators any of above drugs Gap junctions cell-cell communication, small molecules (<1000 MWt) cardiac intercalated disks, smooth muscle fig 3-10d kidney, gut) paracellular pathway between cells fig 3-10b Tight junctions cell “collar”, block large molecules, no lateral protein movement epithelial tissue (esp. Intercellular structures Desmosomes “spot welds”, dense proteins (cytoplasm & intercellular) fibers (intermediate filaments) extend across cells epithelial cells (especially skin), cardiac intercalated disks Tight junctions cell “collar”, block large molecules, no lateral protein movement epithelial cells Gap junctions cell-cell communication, small molecules (<1000 MWt) cardiac intercalated disks, smooth muscleĭesmosomes “spot welds”, dense proteins (cytoplasm & intercellular) fibers (intermediate filaments) extend across cells epithelial cells (especially skin), cardiac intercalated disks fig 3-10a ![]() Phospholipid structure Amphipathic molecule (phosphatidyl choline) hydrophobic part: fatty acids hydrophilic part: phosphate & choline ![]()
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